Molecular determinants analysis and co receptor tropism prediction of V3 loop of HIV-1 “C” clade sequences isolated from India using insilico approach
نویسندگان
چکیده
Background The V3 loop of the env gene in HIV-C type is considered as a major viral determinant for coreceptor specificity. The tip motif of v3 loop is known for antibody neutralization, so sequence variation in this motif have an impact on virus infectivity and disease progression. So analysis of genetic diversity in the V3 loop Tip motif help us to improve the CCR5 antagonist’s development as well as vaccine target.
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